Oseni is an oral tablet used to treat type 2 diabetes. It uses alogliptin and pioglitazone to regulate insulin productions as well as blood glucose levels.Unfortunately, Oseni may cause a devastating skin condition called bullous pemphigoid.
What is Type 2 Diabetes?
Type 2 diabetes is a condition that affects a person’s ability to produce enough insulin to properly check blood glucose (blood sugar) levels. This is usually caused by a poor diet and lack of exercise. It is estimated that over 30 million people have diabetes in the USA, while over 80 million show prediabetic symptoms. Untreated type 2 diabetes can be life threatening, if you experience two or more of the following symptoms contact your doctor immediately:
- Excess thirst
- Urinating a lot
- Gaining or losing weight unintentionally
- Dark skin under armpits, chin, or groin
- Unusual odor to urine
- Blurry vision
Type 2 diabetes often presents no symptoms and remains undiagnosed until a secondary condition presents itself. If you have any of the following risk factors, ask you doctor if a blood test for type 2 diabetes is necessary:
- Having family members with diabetes
- Being overweight
- Inactivity, including watching more than 2 hours of TV a day
- Drinking soda
- Consuming too much sugar and processed food
Though poor diet and lack of exercise are the main causes of this permanent condition, studies continue to find more links to type 2 diabetes, including:
- Stress and stress hormones
- Red meat intake
- Artificial sweeteners
- Foods or drinks with simple carbohydrates
What is Oseni?
Oseni (alogliptin and pioglitazone) is a combination medication used in the treatment of type 2 diabetes. It is administered in a once daily tablet that can be taken with or without food. The drug is designed to increase the pancreases ability to produce insulin, while managing high blood glucose (blood sugar) levels. The alogliptin in Oseni is classified as a DPP-4 inhibitor, a drug class which may be linked to a painful disorder that causes large blisters on the skin.
What is Bullous Pemphigoid?
Bullous pemphigoid is a condition that causes a person’s body to attack its own skin with the antibodies that are usually used to fight off sickness. This is known as an autoimmune disease. This internal attack causes large, fluid filled blisters to form between the first and second layers of skin. These blisters, or bullae, are hard to rupture but one they have the condition site can remain irritated and painful for weeks. The exact causes of bullous pemphigoid are not known, though radiation, UV sunlight and lamps, as well as certain medications (including Oseni) have been shown to increase risk. Patients describe bullous pemphigoid as being incredibly painful. Some symptoms of bullous pemphigoid include:
- Large fluid filled blisters
- Peeling, especially under arms and legs
- Unusual skin pain
- Blisters form deep in skin
If you or a loved one has experienced any of these symptoms while exposed to Oseni, contact your doctor immediately.
Bullous Pemphigoid Causes
Little is known about bullous pemphigoid, though a recent study published in the US National Library of Medicine linked the disease to (DPP)-4 inhibitors like Oseni. These patients showed a direct correlation between the type 2 diabetes drug class and the painful blistering condition. Other than Oseni, scientists have proposed additional links to UV sunlight and sunlamps, radiation and certain medications. Although the disease has somewhat common causes, it has shown to be rare itself; Mostly affecting those over 50 years in age.