Nexium Lawsuit

PPI’s are prescribed to millions of people each year, despite recent reports showing that PPI (Nexium) users have an increased risk of suffering from kidney failure. Nexium has also been linked to kidney inflammation (nephritis), renal disease, and Chronic Kidney Disease.

What is Nexium?

Nexium is a proton pump inhibitor, or PPI drug, marketed by Pfizer. It was approved by the Food and Drug Administration in 2001 for use in treating symptoms of gastroesophageal reflux disease (GERD) and for the healing of erosive esophagitis, a condition associated with GERD.

Also, there seems to be quite a bit of confusion over who owns Nexium.  Under the terms of a 2014 agreement between AstraZeneca (the original developer) and Pfizer; Pfizer acquired the exclusive global rights to market Nexium for the approved over-the-counter indications in the United States, Europe and the rest of the world.

Box of 22.3 mg Nexium

Box of 22.3 mg Nexium

Nexium is commonly prescribed for a variety of stomach issues including acid reflux, ulcers and heartburn. In recent years, reports have surfaced claiming the link between Nexium and a number of acute and chronic injuries. One study published in JAMA Internal Medicine concluded,

“Proton pump inhibitor use is associated with a 20 – 50% higher risk of incident CKD.”

With an end total of 1,921 study participants experiencing chronic kidney disease. Nexium is still being prescribed to patients.

What type of injuries are we investigating?

The following is a list of injuries our law firm is currently investigating related to Nexium side effects.  If you or a loved one has been diagnosed with any of these following Nexium use, you are not alone.

  • Acute Injuries
    • Acute Interstitial Nephritis (AIN)
    • Acute Tubular Necrosis (ATN)
    • Acute Kidney Injury (AKI)
    • Acute Kidney Failure (AKF)
  • Chronic Injuries
    • Chronic Kidney Disease
    • Renal and/or Kidney Failure
    • End Stage Renal Disease (ESRD)
    • Stomach Cancer

Other prescription PPI drugs include:

  • AcipHex
  • Dexilant
  • Kapidex
  • Losec
  • Prevacid
  • Prilosec
  • Protonix
  • Rapinex
  • Vimovo
  • Zegerid

Injured by Side Effects of Nexium?
If you or a loved one has suffered side effects after taking Nexium, you are not alone. To learn how we can help you and your family, please contact us for a Free Case Evaluation. We would be honored to speak with you and will respond promptly to every inquiry we receive.
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What are the side effects of Nexium?

Nexium (esomeprazole) has listed a variety of common and adverse side effects. If you experience any of the symptoms listed below, contact your health care provider immediately.

Common Side effects:

  • Bad, unusual or unpleasant aftertaste
  • Sleepiness or unusual drowsiness
  • Acne
  • Back pain
  • Agitation
  • Dry mouth
  • Excess air or gas in the stomach or intestines
  • Full feeling
  • Hair loss or thinning of the hair
  • Muscular weakness
  • Passing gas
  • Seeing, hearing or feeling things that are not there
  • Swelling of the breasts or breast soreness in both females and males
  • Swelling or inflammation of the mouth
  • Swollen joints

Major Side effects:

  • Blistering, peeling or loosening of the skin
  • Bloating
  • Chills
  • Constipation
  • Cough
  • Darkened urine
  • Difficulty with swallowing
  • Dizziness
  • Drowsiness
  • Fast heartbeat
  • Fever
  • Indigestion
  • Joint or muscle pain
  • Loss of appetite
  • Mood or mental changes
  • Muscle spasms (tetany) or twitching
  • Nausea
  • Pains in the stomach, side, or abdomen; possibly radiating to the back
  • Puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • Red skin lesions, often with a purple center
  • Red, irritated eyes
  • Seizures
  • Skin rash, hives, itching
  • Sore throat
  • Sores, ulcers or white spots in the mouth or on the lips
  • Tightness in the chest
  • Trembling
  • Unusual tiredness or weakness
  • Vomiting
  • Yellow eyes or skin (jaundice)

It is important to note that the initial symptoms of a heart attack often mirror the symptoms of heartburn. If you experience shortness of breath, chest pains or tingling in the shoulders or arms, contact a physician or dial 911 immediately.

What is Chronic Kidney Disease (CKD)?

Chronic kidney disease (CKD) is a potentially fatal disease where the normal function of the kidney is compromised. Kidneys extract waste and excess fluids from the bloodstream, which are then excreted in urine. When their function is compromised, dangerous levels of fluids and waste can build up in the body. The treatment for CKD is usually centered around the underlying cause of the kidney failure. CKD often progresses into end-stage kidney failure, which requires artificial filtering (dialysis) or a kidney transplant as treatment. End-stage kidney failure is often fatal.

Is Nexium linked to Chronic Kidney Disease?

A number of clinical studies have shown a link between PPI (Nexium) use and CDK, with one study showing a 20 – 50% increase in risk for developing the chronic disease. Another study conducted by the Johns Hopkins Bloomberg School of Health, showed an increase in patients prescribed to PPI’s including Nexium. NPR Online quoted Adam Schoenfeld, who co-authored an editorial accompanying the study, as saying,

“When they first came out they weren’t associated with side effects, or we didn’t think they were,”. He went on to state, “So we put [people] on this medication thinking: ‘It’s a quick fix and they’re very safe.’ But in actuality they’re associated with a range of side effects.”

Are there other risks associated with Nexium?

For years, Nexium and other PPI’s were prescribed in staggering numbers, as they were thought to be relatively harmless. After over 20 years on the market, the long-term safety of the drug is being called into question. Recent studies show PPI’s may increase the risk in developing a number of painful and potentially life threatening conditions such as: Rhabdomyolysis (a painful syndrome caused by the release of muscle fibers into the bloodstream), cardiovascular complications, and loss of brain function (hepatic encephalopathy or ‘HE’). Nexium is AstraZeneca’s top product, generating over $30 billion in revenue for the drug giant since its approval in 2001.

Nexium linked to Rhabdomyolysis?

In a recent study conducted by South Korean doctors, a single intravenous dose of Nexium caused a 45-year-old man to suffer a debilitating muscular breakdown, known as rhabdomyolysis. The case report was published in the July edition of the medical journal, Medicine. Rhabdomyolysis is a painful syndrome caused by the release of muscle fibers into the bloodstream. Its symptoms include muscle cramps, tenderness, stiffness, pain or spasms. The condition typically occurs in men over the age of 65 who have renal impairment or uncontrolled hypothyroidism.

Nexium and AstraZeneca Pharmaceuticals LP. in summary:

Nexium is a proton pump inhibitor (PPI) manufactured by Pfizer. It was approved by the Food and Drug Administration in 2001 for use in treating symptoms of gastroesophageal reflux disease (GERD) and for the healing of erosive esophagitis, a condition associated with GERD. In recent years, a number of studies have found a relationship between PPI (Nexium) use and chronic kidney disease (CKD) along with other severe side effects. One study published in JAMA Internal Medicine concluded, “Proton pump inhibitor use is associated with a higher risk of incident CKD.” With an end total of 1,921 study participants experiencing chronic kidney disease.

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