Jentadueto (linagliptin / metformin) is a twice-daily pill that is prescribed in the treatment of type 2 diabetes. It has been associated with a painful autoimmune disorder known as bullous pemphigoid.
What is Jentadueto?
Jentadueto is a drug used to treat type 2 diabetes. It is comprised of two separate medications, linagliptin and metformin; which it uses to manage insulin production as well as regulation of blood glucose levels. It is classed as a DPP-4 inhibitor drug. The combination drug works by regulating insulin production while managing blood glucose levels. Jentadueto is manufactured by Boehringer Ingelheim and was approved by the FDA in January 2012.
What is Type 2 Diabetes?
Type 2 diabetes is a lifelong disease that affects the body’s ability to properly manage blood glucose levels. The disease’s main causes are poor diet and lack of exercise. Once type 2 diabetes has developed, a person’s body loses its ability to produce enough insulin, a hormone that allows your body to process sugar (glucose) from ingested carbohydrates.
This lack of natural insulin can cause high blood sugar (hyperglycemia) or low blood sugar (hypoglycemia). Type 2 diabetes currently affects over 25 Million people in The USA, while over 80 Million show prediabetic symptoms. The sheer numbers of men and women diagnosed with the disease practically ensure that any medication developed to treat it would be incredibly profitable.
What is Bullous Pemphigoid?
Bullous pemphigoid is an autoimmune disease that is characterized by large painful blisters that form deep in the skin. These blisters are difficult to rupture and are generally described as being very painful. The blisters may form anywhere on the body, including the mucus membranes.
The development of bullous pemphigoid has been associated with ultraviolet light and radiation therapy, as well as certain drugs including: furosemide, and other nonsteroidal anti-inflammatory agents, captopril, penicillamine, antibiotics, and most recently DPP-4 inhibitors including Jentadueto.
Bullous Pemphigoid Symptoms?
Only a doctor can properly diagnose and treat bullous pemphigoid. However, if you or a loved one has experienced any of the following symptoms while taking Jentadueto, contact your health care provider immediately:
- Blisters on the arms, legs, abdomen and mucous membranes
- Red rash develops before the blisters
- Large blisters (over quarter size) filled with clear fluid, but may contain some blood
- Thick blisters that do not rupture easily
- Blisters deep in skin
- Red skin around blister area
- Sensitive and painful blisters once ruptured
- Hives and itching
At the time of publication of this article Jentadueto (linagliptin / metformin) is still on the market and has not been recalled.